In this study, we attempted to prepare carbamazepine (CBZ) cocrystal through the solution\nmethod in ethanol-water solvent mixture (volume ratio 1:1) and polyvinyl pyrrolidone (PVP) solution.\nNicotinamide (NIC) and saccharin (SAC) were selected as cocrystal coformers. Cocrystal screening\nproducts were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning\nCalorimetry (DSC), and Powder X-ray Diffraction (PXRD) techniques. Characterization results show\nthat in ethanol-water solvent mixture, pure CBZ-NIC cocrystal can be prepared, while CBZ-SAC\ncocrystal cannot be obtained. The addition of PVP can inhibit CBZ-NIC cocrystal formation and\nfacilitate CBZ-SAC cocrystal formation.
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